版权说明 帮助中心 进入管理中心
首页 > 成果 > 详情

Investigating the optimal size of anticancer nanomedicine.

ESI高被引SCI-EMedline
WOS被引频次:136
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Tang, Li;Yang, Xujuan;Yin, Qian;Cai, Kaimin;Wang, Hua;Chaudhury, Isthier;Yao, Catherine;Zhou, Qin;Kwon, Mincheol;Hartman, James A;Dobrucki, Iwona T;Dobrucki, Lawrence W;Borst, Luke B;Lezmi, Stephane;Helferich, William G*;Ferguson, Andrew L*;Fan, Timothy M*;Cheng, Jianjun*
通讯作者:
Helferich, William G;Ferguson, Andrew L;Fan, Timothy M;Cheng, Jianjun
作者机构:
[Dobrucki, Lawrence W] Bioengineering
[Wang, Hua; Chaudhury, Isthier; Kwon, Mincheol; Yao, Catherine; Yin, Qian; Tang, Li; Cai, Kaimin] Departments of Materials Science and Engineering
[Dobrucki, Iwona T] Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801
[Ferguson, Andrew L] Departments of Materials Science and Engineering, jianjunc@illinois.edu t-fan@illinois.edu alf@illinois.edu helferic@illinois.edu
[Cheng, Jianjun] Departments of Materials Science and Engineering, Bioengineering, jianjunc@illinois.edu t-fan@illinois.edu alf@illinois.edu helferic@illinois.edu
通讯机构:
[Ferguson, Andrew L] Departments of Materials Science and Engineering, t-fan@illinois.edu alf@illinois.edu helferic@illinois.edu
[Cheng, Jianjun] Departments of Materials Science and Engineering, Bioengineering, t-fan@illinois.edu alf@illinois.edu helferic@illinois.edu
[Fan, Timothy M] Veterinary Clinical Medicine, and t-fan@illinois.edu alf@illinois.edu helferic@illinois.edu
[Helferich, William G] Food Science and Human Nutrition, t-fan@illinois.edu alf@illinois.edu helferic@illinois.edu
语种:
英文
关键词:
nanomedicine;size effect;silica nanoparticle;mathematical model;drug delivery
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN:
0027-8424
年:
2014
卷:
111
期:
43
页码:
15344-15349
文献类别:
WOS:Article
所属学科:
ESI学科类别:临床医学;WOS学科类别:Multidisciplinary Sciences
入藏号:
WOS:000343729500035;PMID:25316794
基金类别:
National Institutes of Health (NIH) Director's New Innovator Award Program [1DP2OD007246-01, 1R21CA152627]; NIH National Cancer Institute Alliance for Nanotechnology in Cancer "Midwest Cancer Nanotechnology Training Centre" Grant [R25CA154015A]
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Nanomedicines (NMs) offer new solutions for cancer diagnosis and therapy. However, extension of progression-free interval and overall survival time achieved by Food and Drug Administration-approved NMs remain modest. To develop next generation NMs to achieve superior anticancer activities, it is crucial to investigate and understand the correlation between the physicochemical properties of NMs (particle size in particular) and their interactions with biological systems to establish criteria for NM optimization. Here, we systematically evaluated the size-dependent biological profiles of three monodisperse drug-silica nanoconjugates (NCs; 20, 50, and 200 nm) through both experiments and mathematical modeling and aimed to identify the optimal size for the most effective anticancer drug delivery. Among the three NCs investigated, the 50-nm NC shows the highest tumor tissue retention integrated over time, which is the collective outcome of deep tumor tissue penetration and efficient cancer cell internalization as well as slow tumor clearance, and thus, the highest efficacy against both primary and metastatic tumors in vivo.
参考文献:
Ashley CE, 2011, NAT MATER, V10, P389, DOI [10.1038/nmat2992, 10.1038/NMAT2992]
Benezra M, 2011, J CLIN INVEST, V121, P2768, DOI 10.1172/JCI45600
Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/nnano.2011.166, 10.1038/NNANO.2011.166]
Chaffer CL, 2011, SCIENCE, V331, P1559, DOI 10.1126/science.1203543
Cheng J, 2004, MOL PHARMACEUT, V1, P183, DOI 10.1021/mp049966y

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com