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Antioxidation and Cytoprotection of Acteoside and Its Derivatives: Comparison and Mechanistic Chemistry.

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成果类型:
期刊论文
作者:
Li, Xican;Xie, Yulu;Li, Ke;Wu, Aizhi;Xie, Hong;Guo, Qian;Xue, Penghui;Maleshibek, Yerkingul;Zhao, Wei;Guo, Jiasong;Chen, Dongfeng
通讯作者:
Li, XC
作者机构:
[Zhao, Wei] Zhongshan School of Medicine, Sun Yat-sen University, No. 74 Zhongshan Road. 2, Guangzhou 510080, China. zhaowei23@mail.sysu.edu.cn
[Guo, Jiasong] Department of Histology and Embryology, Southern Medical University, Guangzhou 510515, China. jiasongguo@aliyun.com
[Xue, Penghui] School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. 15228738137@163.com
[Xie, Yulu] School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. xieyulu1900@163.com
[Xie, Yulu] Innovative Research & Development Laboratory of TCM, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. xieyulu1900@163.com
通讯机构:
[Wu, Aizhi; Li, Xican; Xue, Penghui; Maleshibek, Yerkingul; Xie, Hong; Guo, Qian; Xie, Yulu] School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
[Wu, Aizhi; Li, Xican; Xie, Hong; Xie, Yulu] Innovative Research & Development Laboratory of TCM, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
[Li, Ke; Chen, Dongfeng] School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
[Li, Ke; Chen, Dongfeng] The Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
[Guo, Jiasong] Department of Histology and Embryology, Southern Medical University, Guangzhou 510515, China.
语种:
英文
关键词:
acteoside;apiosyl;forsythoside B;phenylpropanoid glycosides;poliumoside;rhamnosyl
期刊:
Molecules (Basel, Switzerland)
ISSN:
1420-3049
年:
2018
卷:
23
期:
2
文献类别:
WOS:Article
所属学科:
ESI学科类别:化学;WOS学科类别:Biochemistry & Molecular Biology;Chemistry, Multidisciplinary
入藏号:
WOS:000426436300278;PMID:29473886
基金类别:
National Science Foundation of China [81573558, 81603269]; Guangdong Science and Technology Project [20217A050506043]; Natural Science Foundation of Guangdong Province [2017A030312009, 2015A030310491]
机构署名:
本校为通讯机构
院系归属:
基础学院
摘要:
The study tried to explore the role of sugar-residues and mechanisms of phenolic phenylpropanoid antioxidants. Acteoside, along with its apioside forsythoside B and rhamnoside poliumoside, were comparatively investigated using various antioxidant assays. In three electron-transfer (ET)-based assays (FRAP, CUPRAC, PTIO center dot-scavenging at pH 4.5), the relative antioxidant levels roughly ruled as: acteoside >forsythoside B > poliumoside. Such order was also observed in H+-transfer-involved PTIO center dot-scavenging assay at pH 7.4, and in three multiple-pathway-involved radical-scavenging assays, i.e., ABTS(+)center dot-scavenging, DPPH center dot-scavenging, and center dot O-2(-)-scavenging. In UV-vis spectra, each of them displayed a red-shift at 335 -> 364 nm and two weak peaks (480 and 719 nm), when mixed with Fe2+; however, acteoside gave the weakest absorption. In Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) analysis, no radical-adduct-formation (RAF) peak was found. MTT assay revealed that poliumoside exhibited the highest viability of oxidative-stressed bone marrow-derived mesenchymal stem cells. In conclusion, acteoside, forsythoside B, and poliumoside may be involved in multiple-pathways to exert the antioxidant action, including ET, H+-transfer, or Fe2+-chelating, but not RAF. The ET and H+-transfer may be hindered by rhamnosyl and apiosyl moieties; however, the Fe2+-chelating potential can be enhanced by two sugar-residues (especially rhamnosyl moiety). The general effect of rhamnosyl and apiosyl moieties is to improve the antioxidant or cytoprotective effects.
参考文献:
Aliaga C, 1998, INT J CHEM KINET, V30, P565, DOI 10.1002/(SICI)1097-4601(1998)30:8<565::AID-KIN5>3.0.CO
2-Q
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Bertolo A, 2017, STEM CELL RES THER, V8, DOI 10.1186/s13287-016-0452-7

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