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Etiology of acute otitis media and phenotypic-molecular characterization of Streptococcus pneumoniae isolated from children in Liuzhou, China

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成果类型:
期刊论文
作者:
Fu, Jinjian;Li, Ling;Liang, Zhuoxin;Xu, Shaolin;Lin, Nan;Qin, Peixu;Ye, Xiaohua*;McGrath, Eric
通讯作者:
Ye, Xiaohua
作者机构:
[Xu, Shaolin; Fu, Jinjian; Qin, Peixu] Liuzhou Matern & Child Healthcare Hosp, Dept Lab, Liuzhou, Peoples R China.
[Li, Ling; Ye, Xiaohua] Guangdong Pharmaceut Univ, Sch Publ Hlth, 283 Jianghai Dadao, Guangzhou 510310, Guangdong, Peoples R China.
[Liang, Zhuoxin] Liuzhou Matern & Child Hlth Care Hosp, Dept Pediat, Liuzhou, Guangxi, Peoples R China.
[McGrath, Eric] Childrens Hosp Michigan, Detroit, MI 48201 USA.
[McGrath, Eric] Wayne State Univ, Sch Med, Detroit, MI USA.
通讯机构:
[Ye, Xiaohua] Guangdong Pharmaceut Univ, Sch Publ Hlth, 283 Jianghai Dadao, Guangzhou 510310, Guangdong, Peoples R China.
语种:
英文
关键词:
Acute otitis media;Streptococcus pneumoniae;Children;Vaccine;Molecular characteristics
期刊:
BMC INFECTIOUS DISEASES
ISSN:
1471-2334
年:
2019
卷:
19
期:
1
页码:
168-
文献类别:
WOS:Article
所属学科:
WOS学科类别:Infectious Diseases
入藏号:
基金类别:
Guangxi Medical and Health Self-funding Project [Z2014379, Z2016531, Z20170509, Z20180022]; Guangxi Nature Science Foundation [2015GXSFBA139129]; Liuzhou Science and Technology Bureau Project [2014 J030422, 2017BD20201, 2018BJ10502, 2018BJ10504]
机构署名:
本校为通讯机构
院系归属:
公共卫生学院
摘要:
BackgroundThe etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptococcus pneumoniae (S.pneumoniae) recovered from Chinese children.MethodsA retrospective study was conducted to enrol patients younger than 18years diagnosed as AOM. Middle ear fluid specimens were collected then cultured for bacterial pathogens. All S.pneumoniae isolates were tested for antibiotic susceptibility, serotypes, virulence genes, antibiotic resistant determinants and sequence types.ResultsThe dominant otopathogen among AOM children was S.pneumoniae (54.4%). Among S.pneumoniae isolates, there were 97.3, 97.3 and 75.7% isolates resistant to erythromycin, tetracycline and trimethoprim-sulfamethoxazole, respectively. There was 72.8% S.pneumoniae with multidrug resistance. The dominant sequence types (STs) were ST271 and ST320, whereas the prevailing serotypes were 19F and 19A. The 7-valent and 13-valent pneumococcal conjugate vaccine (PCV) coverage among AOM children were 73.0 and 94.6%, respectively. Additionally, we found that CC271 expressed more of mef(A/E) (P<0.001), pspA (P=0.022) and sipA (P<0.001) than non-CC271 isolates.ConclusionThe high prevalence of international multidrug-resistant clone (Taiwan(19F)-14) in China necessitates continued dedication to expand PCV13 immunization and better control of antibiotic use in China.
参考文献:
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Coker TR, Chan LS, Newberry SJ, Limbos MA, Suttorp MJ, Shekelle PG, et al. Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review. JAMA. 2010,304(19):2161–9.
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