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Structural elucidation and anti-osteoporosis activities of polysaccharides obtained from Curculigo orchioides.

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成果类型:
期刊论文
作者:
Wang, Xueqian;Zhang, Mengliu;Zhang, Dawei;Wang, Xinluan;Cao, Huijuan;Zhang, Qian;Yan, Chunyan*
通讯作者:
Yan, Chunyan
作者机构:
[Yan, Chunyan] School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: ycybridge@gdpu.edu.cn
[Zhang, Mengliu; Wang, Xueqian; Zhang, Qian] School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
[Zhang, Dawei] Department of Pharmacology, Guangdong Medical University, Dongguan, Guangdong 523808, China
[Cao, Huijuan; Wang, Xinluan] Translational Medicine R&D Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
通讯机构:
[Yan, Chunyan] School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address:
语种:
英文
期刊:
Carbohydrate polymers
年:
2019
卷:
203
页码:
292-301
入藏号:
PMID:30318216
机构署名:
本校为第一且通讯机构
院系归属:
药学院
摘要:
Curculigo orchioides, is a traditional Chinese medicine, is used in strengthening tendons and bones. We evaluated the anti-osteoporosis activity of the crude polysaccharide (CO70) isolated from the rhizomes of C. orchioides in ovariectomized rats. CO70 showed excellent anti-osteoporosis activity comparable to that of 17beta-estradiol. To explore the constituents responsible for the anti-osteoporosis activity of CO70, a novel homogeneous heteropolysaccharide, COP70-3, was isolated and purified from CO70. COP70-3 has a main backbone chain of (1-->5)-linked alpha-L-Araf, (1,3-->5)-linked alpha-L-Araf, (1-->6)-linked beta-D-Galp, (1-->4)-linked beta-D-Manp, (1,2-->5)-linked alpha-L-Araf, (1-->3)-linked beta-L-Rhap, (1, 3-->6)-linked beta-D-Manp, (1-->3)-linked alpha-D-GalpA, (1,3-->6)-linked beta-D-Galp and (1-->6)-linked alpha-D-Glcp residues. Furthermore, 1.87 nM COP70-3 obviously promoted the differentiation of MC3T3-E1 cells, while 0.94 and 1.87 nM COP70-3 significantly improved the osteogenic mineralization rate. These data indicate that COP70-3 has favorable anti-osteoporosis activity in vitro.

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