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Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes.

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WOS被引频次:75
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成果类型:
期刊论文
作者:
Liu, Yun-Jun;Zeng, Cheng-Hui;Huang, Hong-Liang;He, Li-Xin;Wu, Fu-Hai
通讯作者:
Liu, YJ
作者机构:
[Wu, Fu-Hai] Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Guangdong, Peoples R China.
[Liu, Yun-Jun; Zeng, Cheng-Hui; He, Li-Xin] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China.
[Huang, Hong-Liang] Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Guangdong, Peoples R China.
通讯机构:
[Liu, Yun-Jun] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China.
语种:
英文
关键词:
Ruthenium complexes;DNA-binding;Cytotoxicity;Antioxidant activity
期刊:
European journal of medicinal chemistry
ISSN:
0223-5234
年:
2010
卷:
45
期:
2
页码:
564-571
文献类别:
WOS:Article
所属学科:
ESI学科类别:化学;WOS学科类别:Chemistry, Medicinal
入藏号:
WOS:000274773300018;PMID:19932529
基金类别:
National Nature Science Foundation of China [30800227]; Science and Technology Foundation of Guangdong Province [200913030803057]; Guangdong Pharmaceutical University
机构署名:
本校为第一且通讯机构
院系归属:
药学院
公共卫生学院
生命科学与生物制药学院
摘要:
Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes [Ru(bpy)(2)(maip)](ClO(4))(2) (2a) and [Ru(bpy)(2)(paip)](ClO(4))(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH(center dot)). Crown Copyright (C) 2009 Published by Elsevier Masson SAS. All rights reserved.
参考文献:
Arockiasamy DL, 2009, EUR J MED CHEM, V44, P2044, DOI 10.1016/j.ejmech.2008.10.013
BARTON JK, 1984, J AM CHEM SOC, V106, P2466, DOI 10.1021/ja00320a058
BARTON JK, 1984, J AM CHEM SOC, V106, P2172, DOI 10.1021/ja00319a043
Blasius R, 2004, EUR J INORG CHEM, P3971, DOI 10.1002/ejic.200400489
CARTER MT, 1989, J AM CHEM SOC, V111, P8901, DOI 10.1021/ja00206a020

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