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Transcriptomics and Metabonomics of the Anti-Aging Properties of Total Flavones of Epimedium in Relation to Lipid Metabolism.

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成果类型:
期刊论文
作者:
Wu, Bin;Xiao, Xue;Li, Shasha*;Zuo, Guoqing*
通讯作者:
Li, Shasha;Zuo, Guoqing
作者机构:
[Li, Shasha] Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, P.R. China. Electronic address: happylishasha@163.com
[Wu, Bin] Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, P. R. China
[Xiao, Xue] Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China
[Zuo, Guoqing] Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, P. R. China. Electronic address: cqzgqly@163.com
通讯机构:
[Zuo, Guoqing] Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, P. R. China. Electronic address:
[Li, Shasha] Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, P.R. China. Electronic address:
语种:
英文
期刊:
Journal of ethnopharmacology
年:
2018
入藏号:
PMID:30278205
机构署名:
本校为其他机构
摘要:
ETHNOPHARMACOLOGICAL RELEVANCE: Total flavones of Epimedium (TFE) is the main active ingredient in Herba Epimedii, which is a well-known Chinese herbal medicine that is widely used to treat certain age-related diseases in oriental countries. AIM OF THE STUDY: The aim of this work was to investigate the anti-aging properties of TFE related to lipid metabolism. MATERIALS AND METHODS: Both transcriptomics and metabonomics were applied in this work to investigate the anti-aging properties of TFE. Microarray and LC-MS analysis were conducted on liver samples of three groups of rats, including young (4 months), old (24 months), and old rats administrated TFE. RESULTS: Transcriptomics analysis highlighted 287 transcripts related to the anti-aging effect of TFE, in which the expression ratio of 18 genes regulating lipid metabolism, including HMGCS1 and NR1H3, returned to normal levels after TFE treatment. In addition, 24 aging-related metabolites were discovered in a metabonomics study, and 15 of these were structurally identified, including palmitic amide, linoleamide, and oleamide. Bioinformatics and integral data analysis on the results of the transcriptomics and metabonomics suggest the involvement of 12 key metabolic pathways, half of which are highly related to lipid metabolism. CONCLUSIONS: This study demonstrates that the role played by TFE in the lipid metabolism of aging rats is multifaceted and multi-layered.

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