版权说明 帮助中心
首页 > 成果 > 详情

Structural characterization and antineuroinflammatory activity of a novel heteropolysaccharide obtained from the fruits of Alpinia oxyphylla

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
WentingShi;JingZhong;QianZhang;ChunyanYan
作者机构:
School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China
语种:
中文
关键词:
Ethanol (PubChem CID: 702);Sodium hydroxide (PubChem CID: 14798);Sodium chloride (PubChem CID: 5234);Sulfuric acid (PubChem CID: 1118);Trifluoroacetic acid (PubChem CID: 6422);1-phenyl-3-methyl-5-pyrazolone (PubChem CID:70335);Scopolamine hydrobromide (PubChem CID: 6603108);Huperzine A (PubChem CID: 854026);Lipopolysaccharide (PubChem CID: 11970143);Indomethacin (PubChem CID: 3715);Alpinia oxyphylla Miq.;Alzheimer’s disease;Polysaccharides;Antineuroinflammatory activity
期刊:
Carbohydrate Polymers
ISSN:
0144-8617
年:
2020
卷:
229
期:
Volume 229
页码:
115405-
机构署名:
本校为第一机构
院系归属:
药学院
摘要:
The fruit of Alpinia oxyphylla is often used in traditional Chinese medicine to treat dementia and memory defects. In this study, we isolated a novel acidic polysaccharide (AOP70-2-1) from A. oxyphylla fruit. Structural analysis showed that AOP70-2-1 consists of β-D-GlcAp-(1→, →2,3,6)-α-D-Galp-(1→, α-L-Araf-(1→, →2,5)-α-L-Araf-(1→, →4)-α-D-Glcp-(1→, →3,4)-α-D-Xylp-(1→, →3,6)-β-D-Manp-(1→, and α-L-Rhap-(1→. Morphological analysis indicated that AOP70-2-1 had an irregular sheet structure. The crude polysaccharide (AOP70) from A. oxyphylla significantly improved learning and memory ability of Alzheimer’s disease (AD) mice, and AOP70 exhibited comparable or even better effects than huperzine A. Most important, AOP70 reduced NO, IL-1β, TNF-α, and PGE-2 concentrations to normal levels. AOP70-2-1 significantly inhibited NO production in lipopolysaccharide stimulated BV2 microglial cells. Note that the effect of 2.6 μM AOP70-2-1 was superior to indomethacin. AOP70-2-1 also remarkably decreased the values of IL-6 and TNF-α. AOP70-2-1 may be a bioactive component of AOP70 and has the potential for the treatment of AD.

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com