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Potential synergistic effects of Chinese herbal prescription FTZ components detected in blood towards hepatic lipid-modulating targets

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WOS被引频次:3
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成果类型:
期刊论文
作者:
Wang, Laiyou;Tao, Weiye;Luo, Duosheng;Hu, Yinming;Bei, Weijian;Guo, Jiao
通讯作者:
Guo, J
作者机构:
[Wang, Laiyou; Luo, Duosheng; Hu, Yinming; Bei, Weijian] Key Unit of Modulating Liver to Treat Hyperlipidemia SATCM, Level 3 Lab of Lipid Metabolism SATCM, Guangdong TCM Key Laboratory against Metabolic Diseases, Institute of Chinese Medical Sciences, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China
[Tao, Weiye] College of Medical Information Engineering, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China
[Guo, Jiao] Key Unit of Modulating Liver to Treat Hyperlipidemia SATCM, Level 3 Lab of Lipid Metabolism SATCM, Guangdong TCM Key Laboratory against Metabolic Diseases, Institute of Chinese Medical Sciences, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China. Electronic address: jiaoguo_gdpu@hotmail.com
通讯机构:
[Guo, Jiao] Key Unit of Modulating Liver to Treat Hyperlipidemia SATCM, Level 3 Lab of Lipid Metabolism SATCM, Guangdong TCM Key Laboratory against Metabolic Diseases, Institute of Chinese Medical Sciences, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China. Electronic address:
语种:
英文
关键词:
Hyperlipidemia;Multi-target therapeutics;Molecular docking;Virtual screening;Polypharmacology
期刊:
Complementary Therapies in Medicine
ISSN:
0965-2299
年:
2014
卷:
22
期:
5
页码:
887-893
文献类别:
WOS:Article
所属学科:
ESI学科类别:临床医学;WOS学科类别:Integrative & Complementary Medicine
入藏号:
WOS:000344203700008;PMID:25440380
基金类别:
Natural Science Foundation of Guangdong Province, China [S2013010015021]; National Science Foundation of China [81102502]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, China [46]; CSC
机构署名:
本校为第一且通讯机构
院系归属:
医药信息工程学院
摘要:
Objective: Our goal in this study aims to explain the polypharmacological mechanism at the molecular level responsible for the effectiveness of a traditional Chinese medicine (TCM) prescription FTZ to treat hyperlipidernia and related disease. Design: By MDL (R) ISIS_Base 2.5, we constructed a compound database based on the FTZ constituents, which were detected in the rat serum after oral administration of the TCM through ultra-performance liquid chromatography/quadruple-time-of-flight mass-spectrometry (UPLC/Q-TOF-MS/MS) method. After validation of the virtual docking system, we used molecular screening by LigandFit which is a computational method for the shape-directed rapid docking of ligands to target protein active sites, to investigate the interactions between the components in database and lipid-modulating targets in the liver. Results: In the prescription FTZ ingredients, there were sixteen constituents including jatrorrhizine, etc. showed potential effects towards the hyperlipidemia-related targets: HMG-CoA reductase (HMGR), squalene synthase (SQS), oxidosqualene cyclase (OSC), cholesteryl ester transfer protein (CETP), liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisorne proliferator-activated receptors (PPAR(alpha) and PPAR(gamma)). Among the eight herbs in prescription FTZ, Rhizoma Coptidis (RC) plays the most important role in whole effect from FTZ on hyperlipidemia related disease. Conclusions: Our research demonstrated that Chinese medicine formula FTZ has multi-target synergistic effect on hyperlipidemia and suggests the pharmacodynamic material basis could be jatrorrhizine, berberrubine, berberine and salidroside. (C) 2014 Elsevier Ltd. All rights reserved.
参考文献:
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Liu SP, 2012, J BIOL CHEM, V287, P37321, DOI 10.1074/jbc.M112.380063
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