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Prognostic significance of DAPK promoter methylation in lymphoma: A meta-analysis

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成果类型:
期刊论文
作者:
Wang, Hong;Zhou, Lin-Yu;Guan, Ze-Bing;Zeng, Wen-Bin;Zhou, Lan-Lan;Liu, Ya-Nan;Pan, Xue-Yi*
通讯作者:
Pan, Xue-Yi
作者机构:
[Liu, Ya-Nan; Wang, Hong; Guan, Ze-Bing; Zeng, Wen-Bin; Zhou, Lan-Lan; Pan, Xue-Yi] Guangdong Pharmaceut Univ, Dept Hematol, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.
[Zhou, Lin-Yu] Sun Yat Sen Univ, Dept Cardiol, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China.
通讯机构:
[Pan, Xue-Yi] Guangdong Pharmaceut Univ, Dept Hematol, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.
语种:
英文
期刊:
PLOS ONE
ISSN:
1932-6203
年:
2019
卷:
14
期:
1
文献类别:
WOS:Article
所属学科:
WOS学科类别:Multidisciplinary Sciences
入藏号:
基金类别:
Science and Technology Planning Project of Guangdong Province, China [2014A020212415]; Natural Science Foundation of Guangdong Province [2017A030313664]; Science and Technology Project of Guangzhou Yuexiu District [2017-W S-008]
机构署名:
本校为第一且通讯机构
摘要:
We aimed to characterize the clinical significance of epigenetic loss of death-associated protein kinase (DAPK) gene function through promoter methylation in the development and prognosis of lymphoma. PubMed, Web of Science and ProQuest databases were searched for relevant studies. Twelve studies involving 709 patients with lymphoma were identified. The prognostic value of DAPK methylation was expressed as risk ratio (RR) and its corresponding 95% confidence interval (CI), while the associations between DAPK methylation and the clinical characteristics of patients with lymphoma were expressed as odd ratios (ORs) and their corresponding 95% CIs. Meta-analysis showed that the 5-year survival rate was significantly lower in lymphoma patients with hypermethylated DAPK (RR = 0.85, 95% CI (0.73, 0.98), P = 0.025). Sensitivity analysis demonstrated consistent result. However, no associations were found between DAPK methylation and clinicopathological features of lymphoma, in relation to gender (OR = 1.07, 95% CI (0.72, 1.59), P = 0.751), age (OR = 1.01, 95% CI (0.66, 1.55), P = 0.974), international prognostic index (OR = 1.20, 95% CI (0.63, 2.27), P = 0.575), B symptoms (OR = 0.76, 95% CI (0.38, 1.51), P = 0.452), serum lactate dehydrogenase (OR = 1.13, 95% CI (0.62, 2.05), P = 0.683), and BCL-2 expression (OR = 1.55, 95% CI (0.91, 2.66), P = 0.106). Lymphoma patients with hypermethylated DAPK are at risk for poorer 5-year survival rate. DAPK methylation may serve as a negative prognostic biomarker among lymphoma patients, although it may not be associated with the progression of lymphoma.
参考文献:
Amara K, 2008, ANN ONCOL, V19, P1774, DOI 10.1093/annonc/mdn374
Armitage JO, 1998, J CLIN ONCOL, V16, P2780, DOI 10.1200/JCO.1998.16.8.2780
Ben Dhiab M, 2015, CELL ONCOL, V38, P453, DOI 10.1007/s13402-015-0242-8
Chan AWH, 2005, ONCOL REP, V13, P937
Chan WC, 1997, BLOOD, V89, P3909

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