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Three metabolites from the mangrove endophytic fungus Sporothrix sp. (#4335) from the South China Sea.

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WOS被引频次:73
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成果类型:
期刊论文
作者:
Wen, Lu;Cai, Xiaoling;Xu, Fang;She, Zhigang;Chan, Wing Lai;Vrijmoed, L. L. P.;Jones, E. B. G.;Lin, Yongcheng
通讯作者:
She, ZG
作者机构:
[Lin, Yongcheng; Xu, Fang; She, Zhigang; Wen, Lu; Cai, Xiaoling] School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510275, China
[Vrijmoed, L. L. P.; Jones, E. B. G.] Department of Biology Chemistry, City University of Hong Kong, Hong Kong
[Wen, Lu] College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China
[Chan, Wing Lai] Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong
通讯机构:
[She, Zhigang] Sun Yat Sen Zhongshan Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China.
语种:
英文
关键词:
Acetylcholine esterase - Biosynthesis genes - Endophytic fungus - Gene fragments - Genes encoding - Ketosynthase - Protein sequences - South china seas - Spectral datum - Synthase - X-ray diffractive
期刊:
The Journal of organic chemistry
ISSN:
0022-3263
年:
2009
卷:
74
期:
3
页码:
1093-1098
文献类别:
WOS:Article;EI:Journal article (JA)
所属学科:
ESI学科类别:化学;WOS学科类别:Chemistry, Organic
入藏号:
WOS:000263004300016;EI:20091712044620;PMID:19118474
基金类别:
National Natural Science Foundation of China [20772162, 20572136]; 863 Foundation of China [2007AA09Z448, 2006AA09Z422]; Science Foundation of Guangdong Province, China [2007A032600001]; Star Lake Biotechnology Co., Inc., Zhaoqing, Guangdong, China; key Laboratory of Tropical Disease Control; Zhongshan University
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Three metabolites, sporothrins A, B, and C (1-3), were isolated from the mangrove endophytic fungus Sporothrix sp. (#4335). Their structures were identified by the spectral data and X-ray diffractive techniques, with compound 1 showing strong inhibition of acetylcholine esterase. 1,3,6,8- Tetrahydroxynaphthalene (T4HN) was deduced as one of the precursors in the biosynthesis of 1 and 2. In a primary biosynthesis gene study, the partial gene fragment obtained with the LC1-Im/2c-Im primer pair was shown to be closely related to genes encoding T4HN synthase. The deduced protein sequences were highly homologous to the ketosynthase domains of other fungal PKS genes involved in T4HN biosynthesis. ©2009 American Chemical Society.
参考文献:
Bingle LEH, 1999, FUNGAL GENET BIOL, V26, P209, DOI 10.1006/fgbi.1999.1115
Carlos IZ, 2003, SCAND J IMMUNOL, V57, P214, DOI 10.1046/j.1365-3083.2003.01175.x
CHOUDHURY SR, 1994, J NAT PROD, V57, P700, DOI 10.1021/np50108a003
Dai J, 2006, EUR J ORG CHEM, P3498, DOI 10.1002/ejoc.200600261
de Meyer EM, 2008, MYCOLOGIA, V100, P647, DOI 10.3852/07-157R

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